Antimetabolites- Level 3

Drugs- Capecitabine, Cladribine, Cytarabine, Floxuridine,
Fludarabine, Flurouracil, Gemcitabine, Mercaptopurine,
Methotrexate, Pentostatin, Thioguanine
What is it?
 Antimetabolites- Cause Cell Death, Block Cell Progression
 Used For- Acute/Chronic Myelocytic Leukemia, Acute/Chronic
Lymphocytic Leukemia; Rheumatoid Arthritis, Cancer of the
Breast, Colon, Pancreas, Stomach, Rectum; Non-Hodgkin’s
Lymphoma in Children
Side Effects
 Fever, Rash, Freckling, Loss of Hair, Nausea, Vomiting,
Diarrhea, Stomach Pain, Yellowing of the Skin, Acute
Pancreatitis, Dizziness, Headache, Anal Inflammation,
Weakness, Chest Pain, Difficulty Swallowing, Unusual Bruising
or Bleeding, Chills, Sore Throat
 Mouth Care- for Mouth Sores
What can I do?
 See your Health Care Provider- as needed; Birth Control
 See your Pharmacist- for help
 AVOID- Taking with NSAIDs, Lactation, Impaired Liver
Function, Allergic to Antimetabolites
 See a Food Fitness First Registered Dietitian- on
line for help; Small/Frequent Meals, Increase
Fluids